Two sample MR report
HLA-DQA1_Dendritic Cell (DC) against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | 0.1512878 | 0.5301556 | 0.7939325 |
| Weighted median | 5 | -0.2735740 | 0.0430806 | 0.0000000 |
| Inverse variance weighted | 5 | -0.2888183 | 0.0233954 | 0.0000000 |
| Simple mode | 5 | -0.2683866 | 0.0496673 | 0.0056783 |
| Weighted mode | 5 | -0.2676137 | 0.0549366 | 0.0082119 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.131485 | 3 | 0.7694794 |
| Inverse variance weighted | 1.821971 | 4 | 0.7684603 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.1515281 | 0.1823543 | 0.4669524 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 5.68e-05 | 8e-07 | TRUE | 0.5252762 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
